Penelope is the last misanthrope, a mutant immune to a virus causing cannibalism, left in the City of Chicago. Her blood contains the immunity for the virus and the key to a cure. She must first navigate her way out of the city through underground tunnels to citys edge to make her journey to the other misanthropes. This is just the first chapter of the saga and the first game in the Epoch 23 series, games which tell the story of the United States becoming a dystopia of a monarchy.
Before all that, navigate the mazes, avoid the cannibals who become smarter and faster as the game goes on and who dont ever rest, learning the way you play using basic artificial intelligence.